Ceredase (Genzyme)

Ceredase (Genzyme) - General Information

Human Beta-glucocerebrosidase or Beta-D-glucosyl-N-acylsphingosine glucohydrolase E.C. 3.2.1.45. 497 residue protein with N-linked carbohydrates, MW=59.3 kD. Alglucerase is prepared by modification of the oligosaccharide chains of human Beta-glucocerebrosidase. The modification alters the sugar residues at the non-reducing ends of the oligosaccharide chains of the glycoprotein so that they are predominantly terminated with mannose residues

Pharmacology of Ceredase (Genzyme)

Gaucher disease is characterized by a functional deficiency in Beta-glucocerebrosidase enzymatic activity and the resultant accumulation of lipid glucocerebroside in tissue macrophages which become engorged and are termed Gaucher cells. Gaucher cells are typically found in liver, spleen and bone marrow. This can lead to an enlarged spleen and liver (hepatosplenomegaly). Secondary hematologic sequelae include severe anemia and thrombocytopenia. Injections of imiglucerase into Gaucher disease patients leads to elevated serum levels of the enzyme and reduction in the accumulation of glucocerebroside leading to reduced anemia and thrombocytopenia, reduced spleen and liver size, and decreased cachexi.

Ceredase (Genzyme) for patients

Ceredase (Genzyme) Interactions

Ceredase (Genzyme) Contraindications

There are no known contraindications to the use of Cerezyme � (imiglucerase for injection). Treatment with Cerezyme � should be carefully re-evaluated if there is significant clinical evidence of hypersensitivity to the product.

Additional information about Ceredase (Genzyme)

Ceredase (Genzyme) Indication: For the treatment of Gaucher's disease (deficiency in glucocerebrosidase)
Mechanism Of Action: Ceredase (Genzyme) catalyzes the hydrolysis of the glycolipid, glucocerebroside, to glucose and ceramide as part of the normal degradation pathway for membrane lipids.
Drug Interactions: Not Available
Food Interactions: Not Available
Generic Name: Imiglucerase
Synonyms: Acid beta-glucosidase; Beta-glucocerebrosidase; D-glucosyl-N-acylsphingosine glucohydrolase; Glucosylceramidase precursor
Drug Category: Enzyme Replacement Agents
Drug Type: Biotech; Approved

Other Brand Names containing Imiglucerase: Ceredase (Genzyme); Cerezyme (Genzyme Corp);
Absorption: Not Available
Toxicity (Overdose): Not Available
Protein Binding: Not Available
Biotransformation: Not Available
Half Life: 3.6-10.4 min
Dosage Forms of Ceredase (Genzyme): Powder, for solution Intravenous
Chemical IUPAC Name: Human Beta-glucocerebrosidase
Chemical Formula: C2532H3854N672O711S16
Imiglucerase on Wikipedia: https://en.wikipedia.org/wiki/Imiglucerase
Organisms Affected: Humans and other mammals